3A Nanoscale biomolecular interactions in disease

The goal of this programme is to use the nanotechnology toolbox to unravel molecular mechanisms in disease, a key goal of the HTS&M Strategic Research Agenda for Nanomedicine. Program clusters focus on cancer and neurodegenerative diseases and cancer. The projects span the range from understanding fundamental biomolecular conformational changes in disease to understanding DNA rearrangements in cancer using sophisticated nanotechnology-based approaches.

The primary goal of all projects is to understand molecular mechanisms underlying disease processes. The age-related neurodegenerative conditions are a rapidly growing class of diseases prevalent in an increasingly aging population. Cancer is one of the great killers of our time. The societal relevance of this theme and program is indisputable, and results will have impact on clinical practice, diagnostics (Philips, Dannalab), and drug discovery and development (Vertex).Links have been established between individual projects in the clusters to exploit complementarities and synergies in approaches. Clinical relevance is highlighted by active participation of medical researchers in the program (Hubrecht Laboratory, Erasmus Medical Center), and by relevant collaborations in individual projects. Scientific excellence is assured by the involvement of internationally recognized principal investigators, who have demonstrated success (Spinoza, VICI, ERC, and other awards, impeccable publication records).

Back to theme 3: Nanomedicine

Foto: Bram Saeys. 9-6-2011, STW NanoNext Karel V Utrecht

Programme Director:
Prof. dr. Vinod Subramaniam (VU University Amsterdam)