While creating innovative nanotechnology NanoNextNL trains over 200 highly skilled young people. NanoNextNL provides additional training to prepare them for a future as responsible scientific innovators and entrepreneurs. Here you'll find the theses presenting the scientific results of each PhD student trained within NanoNextNL. A scientific and education highlight in its own right.

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129 theses
Magnetic Resonance Imaging for Evaluation and Optimization of Photodynamic Therapy
Magnetic Resonance Imaging for Evaluation and Optimization of Photodynamic Therapy Schreurs, T.

This PhD thesis describes a series of studies on the pre-clinical development and application of magnetic resonance imaging (MRI) techniques for evaluation and optimization of photodynamic therapy (PDT). PDT is an emerging cancer treatment, based on a light-activated drug, called the "photosensitizer".

04-07-2017 View
Numerical methods for diffuse interface models of binary flows
Numerical methods for diffuse interface models of binary flows Simsek, G.

In this thesis, a model for diffuse-interface binary-phase flows have been derived. For the simulation of the model a numerical strategy is developed and implemented considering the application of droplet formation in inkjet processes.

21-06-2017 View
Preclinical evaluation of paramagnetic temperature sensitive liposomes for image-guided drug delivery
Preclinical evaluation of paramagnetic temperature sensitive liposomes for image-guided drug delivery Kneepkens, E.

This thesis describes the preclinical development of image-guided drug delivery from temperature-sensitive liposomes (TSLs) induced by magnetic resonance guided high intensity focused ultrasound (MR-HIFU). Traditional chemotherapy of solid tumors is complicated by a narrow therapeutic window.

19-06-2017 View
Microfluidic methods to study emulsion formation
Microfluidic methods to study emulsion formation Muijlwijk, K.

The focus of this thesis was to use microfluidic methods to study emulsifier adsorption and coalescence stability of emulsions. The underlying thought was to gain better understanding of emulsion formation and physical stability during processing.

01-06-2017 View
Noninvasive therapy monitoring in experimental arthritis
Noninvasive therapy monitoring in experimental arthritis Geest van der, T.

Non-responsiveness to therapy often occurs during treatment of RA. To avoid prolonging ineffective treatments, it is important to ensure effectiveness early upon treatment initiation. With a SPECT scan using anti-FAP antibodies as a tracer, we were able to detect minimal affected joints. After treatment with liposomal prednisolone, a new therapeutic approach for RA, uptake in inflamed joint was lower compared to joints in untreated mice. This indicates that the anti-FAP SPECT scan can be used to monitor the therapeutic efficacy of new drugs.

01-06-2017 View
Writing with a 3D nanopen: magnetic applications of focused electron beam induced deposition
Writing with a 3D nanopen: magnetic applications of focused electron beam induced deposition Sharma, N.

The field of nanotechnology exploits novel functionality in nano-sized particles, nanostructured materials, surfaces and nano-devices arising from their restricted dimensionality.

29-05-2017 View
Myocellular lipid droplets and insulin sensitivity: a microscopy approach
Myocellular lipid droplets and insulin sensitivity: a microscopy approach Gemmink, A.

The prevalance of type 2 diabetes (T2DM) is increasing worldwide. Lipid content in skeletal muscle fibers is higher in T2DM than in control subjects. Intramyocllelar lipid (IMCL) content is negatively associated with insulin sensitivity. However, endurance trained atheletes have IMCL levels simular to patients with T2DM, whilst being insulin sensitive, the so-called athelete's paradox.

24-05-2017 View
Hydration layer dynamics and association mechanisms of food and antifreeze proteins
Hydration layer dynamics and association mechanisms of food and antifreeze proteins Brotzakis, P.

We are able to correlate water reorientation dynamics with the H-bond structure at the hydration shell of anti-freeze proteins. Moreover, by employing Transition Path Sampling and Molecular Dynamics we study how anti-freeze peptides self-assemble into nanotubes, as well as their stability as a function of size.

07-03-2017 View
Metal Organic Frameworks for Gas-Phase Capacitive Sensing
Metal Organic Frameworks for Gas-Phase Capacitive Sensing Sachdeva, S.

This thesis describes a study on gas-phase sensing using capacitive transducers coated with selective affinity layers containing Metal-Organic Frameworks (MOFs).

17-03-2017 View