The primary goal of all projects is to understand molecular mechanisms underlying disease processes. The age-related neurodegenerative conditions are a rapidly growing class of diseases prevalent in an increasingly aging population. Cancer is one of the great killers of our time. The societal relevance of this theme and program is indisputable, and results will have impact on clinical practice, diagnostics (Philips, Dannalab), and drug discovery and development (Vertex).Links have been established between individual projects in the clusters to exploit complementarities and synergies in approaches. Clinical relevance is highlighted by active participation of medical researchers in the program (Hubrecht Laboratory, Erasmus Medical Center), and by relevant collaborations in individual projects. Scientific excellence is assured by the involvement of internationally recognized principal investigators, who have demonstrated success (Spinoza, VICI, ERC, and other awards, impeccable publication records).
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